People forget that the transporter was conceived because the original Star Trek series didn’t have the budget to be constantly landing the ship or even shuttles on planets. It was cheaper to do a lap dissolve superimposed over falling aluminum dust. Later they retconned a bunch of hand-waving explanations around how it works but even if you can get past the fact that people are being murdered and a (presumably exact) replica created at the destination, usually without even a receiving device; the amount of invasive scanning that would be required to reproduce every cell and the brownian motion of every atom would kill the subject in the first place. And if they had all these technological breakthroughs, why wouldn’t they make copies of people. Why wouldn’t a society make a dozen copies of its Einstein? Etc etc. A little thought and the whole concept falls apart.